Skin reactions: rash, pruritus, urticaria. Rarely, severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis have been observed.
Systemic allergic reactions: rarely, systemic allergic reactions (hypersensitivity) may occur following administration of meropenem. These reactions may include angioedema and manifestations of anaphylaxis, such as shock, hypotension, respiratory depression.
Gastrointestinal: abdominal pain, nausea, vomiting, diarrhea. Pseudomembranous colitis has been reported.
Blood: thrombocythemia, eosinophilia, thrombocytopenia, leucopenia and neutropenia (including very rare cases of agranulocytosis), haemolytic anemia, and bleeding. A positive direct or indirect Coombs test may develop in some subjects; there have been reports of reduction in partial thromboplastin time.
Hepatic function: increases in serum concentrations of bilirubin, transaminases, alkaline phosphatase and lactic dehydrogenase alone or in combination have been reported.
Central nervous system: headache, paresthesia, convulsions have been reported but a causal relationship with meropenem has not been established.
Other: oral and vaginal candidiasis.
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